PR-Sapere is an evolving panel of biomarkers that measures senescence and physiologic reserve in peripheral blood. By measuring PR-Sapere in clinical studies on both disease states and healthy aging, we build the scientific foundation to understand how these markers can be applied in the clinic. This knowledge includes three dimensions:
Selecting the right biomarker or biomarkers for each indication and outcome
Establishing thresholds with clinical meaning. These thresholds may be specific to an individual biomarker/indication or may reflect relationships between biomarkers. Further, they may indicate biomarker-associated genetic risk
Interpreting longitudinal changes within individuals based on aging, therapies, interventions, etc.
To-date, PR-Sapere has been used in 16 prospective clinical studies with 10 customers including UNC, City of Hope, St. Jude, and Wake Forest University. PR-Sapere is available for research use only.
Current studies involve a broad range of indications and collaborative structures