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Biomarkers of senescence and physiologic reserve

Biomarkers of senescence drive risk prediction for AKI

Clinical variables

Two clinical variables strengthen the predictive ability of the biomarkers

AKI-Sapere's predictive ability is driven by senescence biomarkers and strengthened by several clinical variables.  In Sapere Bio's discovery study at Duke and Johns Hopkins, common renal biomarkers (sCysC, KIM-1, TIMP-2, L-FABP1, albumin, B2M, NGAL, OPN, UMOD) did not predict AKI before surgery and are therefore not included in AKI-Sapere.