Sapere Bio (formerly HealthSpan Diagnostics) was founded in 2013 by Dr. Norman "Ned" Sharpless and Dr. Natalia Mitin based on research from Dr. Sharpless' lab at the Lineberger Cancer Center, University of North Carolina, Chapel Hill.
Dr. Sharpless' lab was a pioneer in the discovery of mechanisms of aging and predicted the role of senescence in human aging and chronic diseases. Pivotal work from his lab demonstrated a dual role of p16, a marker and regulator of senescence, in tumor suppression and aging.
Building on this knowledge, Sapere Bio is conducting extensive clinical studies of aging biomarkers, including p16, in indications with high unmet need. Our technology allows us to measure physiologic reserve, guide clinical decisions, improve healthcare and save lives.
Dr. Sharpless is the Acting FDA Commissioner and former Director of the National Cancer Institute, while Dr. Mitin leads Sapere Bio.